| Date | Location | Result | |
| Nov 09, 2010 | Wilson, NC | Barton 3, Pfeiffer 1 (25-22,28-26,22-25,25-21) | Box score |
| Nov 6, 2010 | Gaffney, S.C. | Pfeiffer 3, Limestone 2 (22-25,25-21,22-25,25-21,15-13) | Box score |
| Oct 20, 2010 | Misenheimer, NC | Pfeiffer 3, Limestone 0 (25-23,25-21,25-23) | Box score |
| Nov 05, 2010 | Misenheimer, NC | Pfeiffer 3, Converse 0 (25-16,25-12,25-17) | Box score |
| Nov 02, 2010 | Banner Elk, N.C. | Lees-McRae 3, Pfeiffer 0 (25-14,25-15,25-17) | Box score |
| Oct 29, 2010 | Misenheimer, NC | Pfeiffer 3, Erskine 2 (23-25,20-25,25-17,25-21,19-17) | Box score |
| Oct 27, 2010 | Charlotte, NC | Queens 3, Pfeiffer 0 (25-12,25-23,25-14) | Box score |
| Oct 23, 2010 | Misenheimer, NC | Pfeiffer 3, Virginia Union 0 (25-12,25-6,25-9) | Box score |
| Oct 23, 2010 | Misenheimer, NC | Lenoir-Rhyne 3, Pfeiffer 1 (23-25,26-24,25-23,25-10) | Box score |
| Oct 19, 2010 | Misenheimer, NC | Pfeiffer 3, Belmont Abbey 1 (25-19,20-25,25-20,25-23) | Box score |
| Oct 16, 2010 | Mount Olive, NC | Pfeiffer 3, Mount Olive 0 (25-19,25-21,25-15) | Box score |
| Oct 15, 2010 | Wilson, NC | Pfeiffer 3, Barton 0 (25-21,25-19,25-23) | Box score |
| Oct 08, 2010 | Hartsville, SC | Pfeiffer 3, Coker College 2 (25-20,21-25,25-18,26-28,15-13) | Box score |
| Oct 05, 2010 | Misenheimer, NC | Lees-McRae 3, Pfeiffer 1 (23-25,25-19,25-21,25-22) | Box score |
| Oct 01, 2010 | Spartanburg, SC | Pfeiffer 3, Converse 0 (25-21,25-20,25-23) | Box score |
| Sep 26, 2010 | Indian Trail, N.C. | Wingate 3, Pfeiffer 0 (25-19,25-11,25-13) | Box score |
| Sep 25, 2010 | Misenheimer, NC | Pfeiffer 3, Coker 1 (25-12,25-9,27-29,25-21) | Box score |
| Sep 22, 2010 | Misenheimer, NC | Pfeiffer 3, Mount Olive 2 (25-11,25-20,16-25,14-25,15-10) | Box score |
| Sep 18, 2010 | Erskine College | Erskine College 3, Pfeiffer 1 (25-14,25-14,26-28,25-20) | Box score |
| Sep 14, 2010 | Belmont, NC | Belmont Abbey 3, Pfeiffer 1 (20-25,25-21,25-21,27-25) | Box score |
| Sep 11, 2010 | Misenheimer, NC | Montreat 3, Pfeiffer 0 (25-22,25-11,25-21) | Box score |
| Sep 11, 2010 | Misenheimer, NC | North Greenville 3, Pfeiffer 1 (25-12,17-25,25-19,25-20) | Box score |
| Sep 10, 2010 | Misenheimer, NC | Queens 3, Pfeiffer 2 (25-20,17-25,21-25,25-23,15-12) | Box score |
| Sep 07, 2010 | Misenheimer, NC | Barton 3, Pfeiffer 1 (23-25,25-18,25-23,25-18) | Box score |
| Sep 04, 2010 | Salisbury, NC | Lander 3, Pfeiffer 1 (25-13,20-25,25-20,25-18) | Box score |
| Sep 04, 2010 | Salisbury, NC | Armstrong Atlantic 3, Pfeiffer 0 (25-17,25-10,25-18) | Box score |
| Sep 03, 2010 | Salisbury, NC | Elizabeth City State 3, Pfeiffer 0 (25-20,25-22,25-20) | Box score |
| Sep 03, 2010 | Salisbury, NC | Catawba 3, Pfeiffer 1 (25-20,23-25,25-12,25-16) | Box score |